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Course Description

Course fee: $340
Credits: 4.5 (CME, CPE, CNE, AAPA, AANP, CPE for Dietitians, ASWB, APA, Participation)

This nine-module course introduces Dr. Greenblatt’s breakthrough Plus/Minus treatment plan for ADHD patients, while also providing a comprehensive overview of the biochemistry that contributes to this disorder. Treatment strategies such as specific nutrient deficiencies will be discussed in-depth as a supplement or alternative to medication.

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Learning Objectives

Upon completion of this course, registrants will be able to:

  • Define ADHD and how it manifests in all age groups
  • Describe the contributing factors and underlying causes of ADHD
  • Explain the difference between pharmaceutical and nutritional lithium
  • Outline the indications for, and benefits of, nutritional lithium for ADHD treatment
  • Assess the biochemistry of magnesium and its utility in the treatment of ADHD
    Analyze the relationship between zinc and copper and their potential role in ADHD pathology and treatment
  • Review the relationship between lead toxicity and ADHD
  • Illustrate the role of iron deficiency as it relates to ADHD
  • Summarize the biochemical role of specific B vitamins in mental health
  • Assess the potential of vitamin D for ADHD treatment
  • Describe the reasoning and use of amino acid neurotransmitter precursors for mental health
  • Evaluate the potential benefits and utility of omega-3 fatty acids for ADHD
  • Outline the role of nutrition and ultraprocessed foods in mental health and ADHD
  • Summarize the effects of excess sugar consumption on ADHD
  • Evaluate the relevance of celiac disease and ADHD
  • Describe the biochemistry and potential mental health effects of casomorphin and gliadorphin
  • Assess the relationship between food allergies and ADHD
  • Apply the findings in the literature on addressing food additives and ADHD symptoms
  • Assess the relationship between gut flora and mental health
  • Utilize treatments to address gut flora imbalances, including probiotics and antimicrobials
  • Appraise the relevance of brain waves and ADHD
  • Distinguish the potential benefits of OPCs and their effects on mental health and ADHD symptoms

Modules

1. ADHD Overview & Basics

  • What is/isn’t ADHD and who gets ADHD
  • Common comorbidities
  • Standard treatment approach – medications & therapy
  • Standardized medicine vs. biochemical individuality
  • Symptoms
  • ADHD neurobiology and biologic bases
  • Nutrition
  • The functional psychiatry treatment model
  • The Plus-Minus Plan
  • Why test?
  • Foundational biomedical assessments for ADHD
  • A reimagining of the therapeutic alliance
  • Hope and healing

2. Nutritional Lithium

  • Lithium: Examining the element, mineral, medicine
  • Nutritional vs. pharmaceutical lithium
  • Understanding the lithium dose-response curve
  • Symptoms of lithium deficiency
  • Lithium’s natural history
  • Lithium deficiency and the research
  • Tap water studies and suicide rates
  • Lithium as a pharmaceutical
  • The unique role of lithium in the treatment ADHD
  • Clinical indicators of potential lithium deficiency
  • Research and implications of untreated irritability
  • Clinical evidence for lithium and mood stabilization
  • Disruptive Mood Dysregulation Disorder
  • Aggression
  • Conduct Disorder
  • ADHD case studies
  • Lithium’s pleiotropic mechanisms of neuroprotection
  • Why lithium for ADHD?
  • Lithium carbonate vs. lithium orotate
  • Recommended testing
  • Clinical indicators of low lithium
  • A closer look at safety profiles (lithium carbonate vs. orotate)
  • Lithium orotate safety studies

3. Minerals

  • Defining “essential” nutrition
  • Primary roles of essential nutrients in human biology
  • Magnesium
    • Biologic roles
    • Deficiencies, contributors and common deficiency symptoms
    • Magnesium deficiency and supplementation in ADHD
    • Testing, clinical indicators, supplementation and formulations
  • Zinc & Copper
    • Role of zinc in CNS, neurotransmitter synthesis and digestion
    • Zinc deficiencies, research, ADHD and supplementation
    • Augmentation and zinc:copper ratios/relationship
    • Health implications and behavioral effects of high copper
    • Copper toxicity, dopamine disruptions, and neurocognition
    • Testing and supplemenation
  • Lead
    • Common sources and water supply
    • Lead exposure and health effects
    • Lead and ADHD research
    • Blood levels and testing
  • Iron
    • Biologic functions
    • Symptoms of deficiency
    • Iron, ferritin levels, and ADHD

4. Vitamins

B VITAMINS

Folate

  • Biologic roles and folate metabolism
  • Risk factor for folate deficiency
  • MTHFR genetic variants
  • Research snapshot
  • Folate and depression
  • Folate supplementation for psychiatric illness
  • Recommendations, testing, and supplementation

Vitamin B12

  • Biologic roles and neurotransmitter synthesis
  • B12 deficiency: physiologic & neurocognitive symptoms
  • Research snapshot: B12 and folate levels in ADHD
  • Normal and optimal levels
  • Recommendations, testing, and supplementation

Vitamin B6

  • Biologic roles (enzymatic cofactor, glucose regulation, energy production, neurotransmitter synthesis)
  • Research snapshot on B6 and depression, and B6 supplementation for psychiatric health
  • Pyroluria (description, etiology, impacts on B6 and zinc levels, symptoms)
  • B6: Recommendations for testing and treatmen

Thiamine

  • Dietary factors impacting B vitamin status
  • Thiamine roles and thiamine deficiency; implications for health
  • B Complex: Recommendations for supplementation

Vitamin D

  • Roles in physical and neurologic health
  • Vitamin D and serotonin
  • Deficiency prevalence
  • Research snapshot: Vitamin D and ADHD, and deficiency in ADHD
  • Supplementation for ADHD symptoms
  • Vitamin D + magnesium: synergistic effects
  • Recommendations, testing and understanding results
  • Supplementation / biochemical individuality
  • Routine monitoring

Vitamin C

  • Roles in the body and in neurotransmitter synthesis
  • Common causes of depletion
  • Vitamin C and ADHD

5. Amino Acids & Essential Fatty Acids

Amino Acids

  • Neurotransmitter regulation and dopamine
  • Protein digestion: macromolecules to amino acid precursors
  • Amino acids and neurotransmitter levels/activity
  • Lessons from Acute Tryptophan Depletion (The ATD protocol, and neurobehavioral effects of ATD and implications for psychiatric treatment)
  • Indicators of amino acids status
  • Research snapshot: amino acid levels and transport in ADHD populations
  • Recommendations, testing and Supplementation, broad-spectrum support, and targeted support for tryptophan, 5-HTP and L-Tyrosine)

Essential Fatty Acids (EFA)

  • The essentiality of essential fats and classes of EFAs
  • Roles in nervous system health (membrane fluidity and neurotransmission)
  • Physical and neuropsychiatric indicators of EFA deficiency
  • Research snapshot:
    • EFA deficiency and suicidality
    • Omega-3 levels in ADHD
    • Genetic factors influencing EFA status in ADHD
    • Omega-3 supplementation for ADHD
    • Adjunctive Omega-3 treatment
  • The Omega-3:Omega-6 ratio and implications
  • Recommendations, testing and supplementation

6. Ultra-Processed Foods & Glycemic Balance

  • What is “Ultra-Processed Food” (UPF)?
  • UPF in the Standard American Diet
  • Research snapshot (effects of UPF intake on health, and correlations of UPF intake to ADHD)
  • Refined added sugar (sources of refined, added sugars, sugar-sweetened beverages [SSBs])
  • Research snapshot: SSBs and behavior
  • The Glycemic Index
  • ADHD and abnormal glucose tolerance
  • Research snapshot (ADHD and reactive hypoglycemia; obesity, diabetes, and ADHD
  • Neurobehavioral implications of reactive hypoglycemia
  • Recommendations for removing sugar, glycemic stabilization, and carbohydrate balance

7. Food Allergies & Dietary Exorphins

  • The right food may be the wrong food!
  • Celiac disease: pathophysiology, long-term health effects, symptoms, prevalence of asymptomatic Celiac, ADHD/Celiac connections, impact on nutritional interventions
  • Recommendations for testing and Celiac screening
  • Dietary Exorphins
  • Casomorphin & gliadorphin – dietary exorphins and morphine analogs!
  • Opioids
  • Endorphins vs. exorphins
  • Dipeptidylpeptidase-4 (DPP-IV) function and implications for protein digestion
  • Formation of opiates from food
  • Morphine variable responses
  • High dietary exorphin levels
  • Lab testing
  • IgE-mediated food allergies
  • Allergic conditions and prevalence in ADHD populations
  • IgE allergies, mechanisms, and primary manifestations
  • Food allergy symptoms (physical & neurobehavioral)
  • Elimination diets
  • The Feingold Hypothesis
  • Health consequences of artificial colors
  • Research snapshot for removing artificial colors and additives

8. Gut-Brain Axis & Dysbiosis

  • Basics of the Gut-Brain Axis (GBA): function, Enteric Nervous System, GBA functions, contributions to neurologic health
  • Dysbiosis: physical & neurobehavioral indicators, psychiatric disorders
  • Research on dysbiosis links with psychiatric illness and severity; antibiotic use implications; dysbiosis in ADHD populations
  • Diet: most direct and significant factor influencing the GBA
  • Probiotics: research, probiotics for mental health (depression, anxiety, mood, cognitive performance), and probiotics for ADHD
  • Specific pathogens
    • Candida: symptoms of Candida overgrowth; testing and organic acids; treatments
  • Clostridia & 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA)
    • How HPHPA disrupts the dopamine pathway
    • Clinical indicators of Clostridia overgrowth/HPHPA
    • Testing, organic acids and treatments
  • GBA health to support ADHD treatment (testing, probiotics supplementation, and specific recommendations for Candida, Clostridia/HPHPA)

9. OPCs & Parenting

  • Neural oscillations (brainwaves): EEG frequency bands, implications
  • EEG patterns in ADHD, and interventions to rebalance brainwaves
  • Neurofeedback pros and cons
  • Rebalancing brainwaves with OPCs
    • What are OPCs and their benefits
    • Mechanisms underlying OPC therapeutic effects
  • Research on OPCs and cognition and OPCs for ADHD
  • Curcumin and mechanisms of action
  • Case study data on OPCs for ADHD
  • Recommendations and supplementation
  • Broad-spectrum micronutrients
  • Nurturing
    • How criticism impacts developmental trajectories
    • Methods for reorienting confrontation: S.A.I.L.
    • Unconditional listening for improving parent-child communication
    • Key tips for parents
    • The ADHD child’s “bill of rights”

Enrollment grants students access to educational curriculum for one year from course purchase date. All refunds must be requested within seven (7) days of enrollment. In order to qualify for a refund, learners must have progressed through less than 10% of the educational content in question. All refunds will be processed minus a 10% transaction fee.

This course was one of the best Psychiatry Redefined Courses offered by Dr. Greenblatt. The wealth of information presented is extensive and I have a very fat binder in which to organize it for future reference! I consider this course to be up there with the best courses of my career.

Suzanne N.

I loved the breakdown of the step by step approach to managing and treating ADHD. The course helped answer questions I had from reading the book, and give a more complete approach, that requires the clinician to view the patient as a whole, and not just a collection of symptoms or diagnoses.

Juliana N.

Good, concise. Excellent synopsis of micro/macronutrients to consider.

Sonya M.

This was so helpful. It will be important to begin to use this knowledge to help patients with ADHD address their unique symptoms and biochemistry in a comprehensive way vs. medication management only.

Paula A.

Excellent presentation of material. Excellent review of material much of which is not generally known or practiced. Finally Focused has been an excellent primer for me.

Kathleen H.

Excellent. Very informative. Well designed format.

Delores A.

Great course. Good readings and very informative.

Joann G.

This was a very informative course. It offered great information on ADHD.

Sophia S.

A MUST for anyone practicing integrative medicine.

Cocó M.

"I can't thank you enough. I cannot tell you how many countless patients I could have already helped with this information!"

Michelle K.

Accreditation Information

Provided by HMP Education and Psychiatry Redefined, HMP Global Companies.

Click to View CME Information

FACULTY  
James Greenblatt, MD
Founder, Psychiatry Redefined
Assistant Clinical Professor of Psychiatry
Tufts University School of Medicine
Boston, Massachusetts

INTENDED LEARNERS  
This educational activity is specifically designed for healthcare and mental healthcare clinicians and professionals involved and/or interested in the treatment of patients with symptoms of ADHD.

LEARNING OBJECTIVES  
After participating in this activity, learners should be better able to:

Module 1: 

· Define ADHD and how it manifests in all age groups
· Describe the contributing factors and underlying causes of ADHD

Module 2: 

· Explain the difference between pharmaceutical and nutritional lithium
· Outline the indications for, and benefits of, nutritional lithium for ADHD treatment

Module 3: 

· Assess the biochemistry of magnesium and its utility in the treatment of ADHD
· Analyze the relationship between zinc and copper and their potential role in ADHD pathology and treatment
· Review the relationship between lead toxicity and ADHD
· Illustrate the role of iron deficiency as it relates to ADHD

Module 4:

· Summarize the biochemical role of specific B vitamins in mental health
· Assess the potential of vitamin D for ADHD treatment

Module 5: 

· Describe the reasoning and use of amino acid neurotransmitter precursors for mental health
· Evaluate the potential benefits and utility of omega-3 fatty acids for ADHD

Module 6: 

· Outline the role of nutrition and ultraprocessed foods in mental health and ADHD
· Summarize the effects of excess sugar consumption on ADHD

Module 7:

· Evaluate the relevance of celiac disease and ADHD
· Describe the biochemistry and potential mental health effects of casomorphin and gliadorphin
· Assess the relationship between food allergies and ADHD
· Apply the findings in the literature on addressing food additives and ADHD symptoms

Module 8: 

· Assess the relationship between gut flora and mental health
· Utilize treatments to address gut flora imbalances, including probiotics and antimicrobials

Module 9: 

· Appraise the relevance of brain waves and ADHD
· Distinguish the potential benefits of OPCs and their effects on mental health and ADHD symptoms

ACTIVITY OVERVIEW
This nine-module course introduces Dr. Greenblatt’s breakthrough Plus/Minus treatment plan for ADHD patients, while also providing a comprehensive overview of the biochemistry that contributes to this disorder. Treatment strategies, such as specific nutrient deficiencies, macro- and micronutrients, amino acids precursors, lithium, diet, inflammation and more, will be discussed in-depth as a supplement or alternative to medication.

This on-demand webcast is available with synchronized slides and video/audio.

To be eligible for documentation of credit for each session attended, learners must participate in the activity and complete the activity evaluation. Participants who complete the evaluation online within active dates of the training will receive documentation of credit. Your certificate may not load if you are accessing it from a smartphone, or if your browser settings do not allow a new tab/window to open.

Once a certificate has been claimed, physicians and pharmacists may elect for credits to be submitted on their behalf to their boards via additional fields that will appear within the Claim Certificate page. Credits must be submitted through this process to be reported to the American Board of Surgery and the National Association of Boards of Pharmacy.

Release Date: December 10, 2025
Expiration Date: December 31, 2026
Estimated Time to Complete: 4.5 hours 

There is no fee for current Psychiatry Redefined Fellows or members. A fee of $340 applies for non-members who wish to access this on-demand activity. This on-demand activity is included for those who enroll in the ADHD intensive training program for $399.

HARDWARE/SOFTWARE REQUIREMENTS
The activity is best supported via a computer or device with current versions of the following browsers: Mozilla Firefox, Google Chrome, or Safari. A PDF reader is required for print publications.

CONTINUING EDUCATION  

In support of improving patient care, this activity has been planned and implemented by HMP Education and Psych Redefined. HMP Education is jointly accredited by the

Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Note: This statement is not an indication of approved credits. Please see below for full accreditation details, including credit types and totals, for this activity.

PHYSICIANS
HMP Education designates this internet enduring activity for a maximum of 4.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PHARMACISTS
This internet enduring, knowledge-based activity (Universal Activity Number: JA0006201-9999-25-545-H01-P has been approved for a maximum of 4.5 contact hours (0.45 CEUs).

Note: The certificate is not the official record of your participation in the activity. The official record of credit will be the information in the CPE Monitor system. Following ACPE Policy, credit must be transmitted to NABP through CPE Monitor within 60 days from the date you complete this CPE activity

NURSES
This continuing nursing education internet enduring activity awards 4.5 contact hours. Provider approved by the California Board of Registered Nursing, Provider #18006, for 4.5 contact hours.

NURSE PRACTITIONERS
American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 CreditTM from organizations accredited by the ACCME.

PHYSICIAN ASSOCIATES/ASSISTANTS  

HMP Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit(s) for activities planned in accordance with the AAPA CME Criteria. This internet enduring activity is designated for 4.5 AAPA Category 1 credits. Approval is valid until December 31, 2026. PAs should only claim credit commensurate with the extent of their participation.

DIETITIANS

Completion of this RD/DTR profession-specific of IPCE activity awards CPEUs (One IPCE credit = One CPEU). If the activity is dietetics-related but not targeted to RDs or DTRs, CPEUs may be claimed which are commensurate with participation in contact hours (One 60 minute hour = 1 CPEU). RDs and DTRs are to select activity type 102 in their Activity Log. Peformance indicator selection is at the learner’s discretion.

PSYCHOLOGISTS  

Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs. This enduring activity awards 4.5 CE Credits.

SOCIAL WORKERS
As a Jointly Accredited Organization, HMP Education is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this internet enduring course receive 4.5 continuing education credits.

NATUROPATHIS PHYSICIANS
The activity is certified for AMA PRA Category 1 Credit™, ANCC nursing credit, and/or ACPE pharmacy credit. The following states currently accept one or more of these credit types toward naturopathic CE requirements: Arizona, California, Maine, Minnesota, New Mexico, Oregon, Washington, and Wisconsin. Naturopathic doctors (NDs) licensed in these states may be eligible to apply the credit earned from this activity toward their CE requirements. Licensees are responsible for verifying applicability with their state licensing board, as acceptance criteria may vary and are subject to change.

USE OF PROPRIETARY NAMES
This continuing medical education activity may include device or medicine brand names for participant clarity purposes only, due to the presence of different branded versions of the same product. No product promotion or recommendation should be inferred.

UNAPPROVED AND/OR INVESTIGATIONAL USES OF DRUGS AND DEVICES
This activity may contain information about experimental and other uses of drugs or devices that are not currently approved by the European Medicines Agency (EMA) of the European Union or the Food and Drug Administration (FDA) of the United States. Participants are strongly encouraged to consult approved product labeling for any drug or device mentioned in this activity before use. The opinions expressed during this activity are the opinions of the respective authors, presenters, or moderators and do not necessarily reflect the opinions of HMP Education.

DISCLAIMERS
The material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a provider-patient relationship. Medical advice of any nature should be sought from an individual’s own healthcare provider.

The opinions expressed in this educational activity are those of the faculty and are not attributable to HMP Global or any of its subsidiaries or affiliates. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.

DISCLOSURE OF RELEVANT FINANCIAL RELATIONSHIPS
HMP Education is an independent provider of continuing medical education. HMP Education has no proprietary or financial interest in medical or healthcare products over which the FDA (USA) or EMA (EU) has regulatory authority.

In accordance with our disclosure policies, HMP Education is committed to ensuring balance, independence, objectivity, and scientific rigor for all accredited continuing education. These policies include assigning relevance to and mitigating all perceived or real relevant financial relationship (conflicts of interest) between any individual with control over the content and any ineligible company (commercial interest) as defined by the ACCME and CPME.

Any individual with control over accredited content, including planner, faculty, and reviewer, is required to globally disclose:

1. Individual relationship(s) or lack thereof, and its nature, with any/all ineligible company, and;
2. Any investigational, off-label, or non-FDA approved content or discussion

HMP Education has reviewed these disclosures, assigned relevance based on the relationship and scope of content, and identified those with the potential to compromise the goals and educational integrity of the education. Relevant relationships, or lack thereof, are shared with the learner.

Education has been independently peer-reviewed to validate content, mitigate identified financial relationships (conflicts of interest), and ensure:

1. All recommendations involving clinical medicine are based on evidence that is accepted within the medical profession as adequate justification for their indications and contraindications in the care of patients.
2. All scientific research referred to, reported, or used in accredited continuing education in support or justification of a patient care recommendation conforms to generally accepted standards of experimental design, data collection, and analysis.
3. Content is appropriate, fair and balanced, unbiased, referenced, and non-promotional.

All relevant financial relationships have been mitigated. 

FACULTY
The faculty have reported the following:

James Greenblatt, MD: Speaker- Pure Encapsulations; Founder & Author Royalties—Psychiatry Redefined

PLANNING COMMITTEE
Planning for this activity was conducted by faculty advisors. To further support the development of the content, additional information regarding professional roles, responsibilities, and teamwork was gathered through survey input from our target audience and/or a comprehensive literature review.

HMP Education planners and staff include Brielle Calleo; Heather Getz; James Greenblatt, MD; Samantha Joy; Randy Robbin; and Andrea Zimmerman, EdD, CHCP.

James Greenblatt, MD: Speaker—Pure Encapsulations; Founder & Author Royalties—Psychiatry Redefined

No other HMP Education staff has disclosed a relevant financial relationship with any ineligible company (commercial interest).

ADA STATEMENT
HMP Education complies with the legal requirements of the Americans with Disabilities Act and the rules and regulations thereof. Any participant in this educational activity who needs accommodation(s) may submit a request to the support team.

PRIVACY POLICY
HMP Education protects the privacy of personal and other information regarding participants, educational partners, and joint providers. HMP Education and our joint providers will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting purposes to the appropriate accrediting agency. HMP Education maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

COMMERCIAL SUPPORT
No commercial interest provided financial support for this continuing education activity.

CONTACT US
For immediate assistance, please explore our HMP Education Help Center or chat with our Virtual CE Assistant, which can answer most common questions related to claiming credits and the HMP Education website. If you have a question or grievance that cannot be answered by our Virtual CE assistant and Help Center, please contact the support team. Our accreditation and compliance team will respond to your inquiry within one business day.

Copyright © 2025 by HMP Education. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from HMP Education.

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