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Course Description

Course Fee: $170

This two-module course taught by Dr. James Greenblatt explores the clinical challenges of treating Binge-Eating Disorder and illuminates an evidence-based functional medicine model for treatment.  The New Hope Model integrates lab testing, nutritional supplementation, dietary modifications, and medication, and targets biochemical pathways that regulate appetite, allowing clinicians to address imbalances that perpetuate hunger and cravings and bring patients back into balance.

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Learning Objectives

Upon completion of this course, participants will be able to:

  1. Describe one way that neurotransmitter regulation affects hunger and satiety signaling.
  2. List three common causes of functional amino acid deficiency.
  3. Discuss one example of how 5-HTP can affect appetite regulation.


Module 1

  1. An Introduction to BED
    1. Overview & DSM diagnostic criteria
    2. Key features of BED
    3. Epidemiology and statistics
  2. Elucidating a biologic model of BED pathogenesis
    1. The neurochemistry of appetite
    2. Neurotransmitter regulation of hunger and satiety signaling
  3. The Building Blocks of Neurotransmitters: Amino Acids
    1. Common causes of functional amino acid deficiency
    2. Zinc, hydrochloric acid, and protein digestion
    3. Cognitive and behavioral sequelae of tryptophan depletion
    4. 5-HTP for appetite regulation
    5. Cognitive and behavioral sequelae of phenylalanine depletion
    6. Nutritional strategies for addressing amino acid imbalance, depletion for appetite
  4. Neural Correlates of Food Addiction
    1. MSG
    2. Sugar

Module 2

  1. Opiate Neuropeptides: Casomorphin & Gliadorphin
    1. The formation of opiate peptides from incomplete protein digestion
    2. Neurochemical, cognitive and behavioral sequelae of opiate peptide CSF influx
    3. Laboratory testing for casomorphin & gliadorphin
  2. Vitamin B12
    1. Symptoms and mental health implications of functional B12 deficiency
    2. Proton-pump inhibitors and B12 deficiency
    3. B12 blood levels: elucidating “normal”
  3. Folate (Vitamin B9)
    1. Folate deficiency: exogenous and endogenous risk factors
    2. Genetic polymorphisms: the MTHFR gene
    3. MTHFR SNPs: treatment implications
  4. Vitamin B6 (pyridoxine)
    1. Functions: energy metabolism, enzymatic function, nutrient absorption
    2. Role in the serotonin synthesis pathway
  5. Vitamin D
    1. Role in the serotonin synthesis pathway
    2. Environmental factors in vitamin D deficiency
    3. Vitamin D deficiency and inflammation
  6. Magnesium
    1. Role as enzymatic cofactor
    2. HPAA influences
    3. Magnesium and GABA receptor function
    4. Causes of magnesium depletion
    5. Clinical pearls: indicators of deficiency, recommended formulations
  7. The Thyroid Master Regulator
    1. Signs and symptoms of hypothyrodism, hyperthyroidism.
  8. Gut Microbial Influences on Appetite & Feeding Behaviors
    1. Exploring the gut-brain axis
    2. Factors contributing to dysbiosis
    3. Implications of reduced microbial diversity
    4. Gut microbiota and appetite: the research
  9. Medications
    1. Reframing perspectives: where medications ‘fit’ in the functional psychiatry toolbox
    2. Medications for BED
      1. Fluoxetine (Prozac)
      2. Topiramate (Topamax)
      3. Lisdexamfetamine (Vyvanse)
      4. Naltrexone / Low-Dose Naltrexone
      5. Dasotraline
  10. The New Hope Model
    1. Review of the New Hope Model
    3. Nurturing the Body-Mind
    4. The “Un-Diet”: Mindful Eating
    5. CBT to support functional treatment
    6. Conclusion

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Integrative Medicine for Binge-Eating

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Learn how appetite is controlled by the brain’s neurochemical systems, plus traditional and complementary approaches for recovery. This book offers a permanent solution based on scientific research to help you reclaim a healthy relationship with food and end the vicious cycle of food addiction.

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