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Course Description

Course fee: $259
CME: 5.75 AMA PRA Category 1 Credits™

Schizophrenia is a challenging condition to treat, often with lifelong consequences. A number of nutritional and integrative approaches appear to hold some promise in reducing symptoms, typically with lower risks for side effects. Developed with support from the International Society for Orthomolecular Medicine, this course reviews the history and the research around integrative approaches to schizophrenia treatment. Additionally, you will learn about micronutrient deficiencies, toxic neurochemical aggregations, systemic inflammation, and other etiologic factors as they pertain to the treatment of schizophrenia and psychosis.

Learning Objectives

Upon completion of this course, participants will be able to:

  • Identify the key genetic, nutritional, metabolic, and environmental causes of schizophrenia and psychosis
  • Understand orthomolecular medicine and its contributions to medical science
  • Know the micronutrient deficiencies, food allergens, gut dysbiosis, and macronutrient deficiencies that exacerbate psychosis and schizophrenia
  • Learn how to run and read diagnostic tests in the evaluation of patients’ symptoms
  • Describe the essential tenets and clinical implications of Horrobin’s Neurodevelopmental Hypothesis and the Phospholipid Hypothesis
  • Employ a functional medicine approach for better patient outcomes at your clinic or practice


1. Schizophrenia in Perspective

The first module shows the genetic and epigenetic influence on presentation of symptoms of schizophrenia/psychosis, revealing the illness to be an accumulation of innate and acquired biochemical deficiencies. We introduce a new integrative care model for schizophrenia that targets both the brain and body, environmental toxins, and other therapies.

2. A History of Orthomolecular Medicine

Module 2 offers a history of orthomolecular medicine and its pioneers, seguing into an examination of the use of niacin, vitamin C, and NAC in the treatment of schizophrenia.

3. Mastering Balance: Vitamin Deficiencies & Dependencies

This module is devoted to showing the association between several micronutrients—B vitamins (folate, B6 and B12), vitamin D, and zinc—and the presentation of symptoms of psychosis.

4. Inflammation, Gluten, and Dairy

Module 4 takes a deep dive into food hypersensitivities (allergies, intolerances, reactions) that exacerbate psychosis, as well as environmental, biochemical, and genetic factors that contribute to oxidative stress.  We will review biomarkers of inflammatory status and their associations with psychiatric disorders. The pathophysiology and therapeutic repercussions of celiac disease will be elucidated, bringing to the forefront of discussion the long-established link between diet and mental health. The module will conclude with a review of the gut-brain axis, the role of gut microbiota in neurologic health, and the implications of gut dysbiosis as they pertain to integrative treatment strategies for schizophrenia.

5. Orthomolecular Models for the Treatment of Schizophrenia

This module examines the prominent theories informing functional medicine approaches to psychosis. Providing an overview of the macronutrient deficiencies (such as dietary lipids and amino acids) that can present as psychosis, we conclude with an objective assessment of the efficacy of non-drug treatment options for this disease.

Enroll Now

Course registration fee subsidized by the International Society for Orthomolecular Medicine.

This is very helpful because it includes the history of schizophrenia and psychosis; it discusses the conventional meds vs. nutritional remedies. The examples of studies are very helpful.

Anita D.

Excellent. Best treatment strategies for schizophrenia.

Debra B.

Right on. Excellent!

Ivonne B.

Very informative!

Laura L.


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Accreditation Information

Please click to expand each section and view accreditation information.

• CME Information

June 20, 2022 through June 19, 2024

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of MedicusCME and Comprehensive Psychiatric Resources, Inc.  MedicusCME is accredited by the ACCME to provide continuing medical education for physicians.

MedicusCME designates this live activity for a maximum of 5.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Schizophrenia is a challenging condition to treat, often with lifelong consequences. A number of nutritional and integrative approaches appear to hold some promise in reducing symptoms, typically with lower risks for side effects. This course reviews some of the history and the research around integrative approaches to schizophrenia treatment.


  • Describe the background, history and efficacy of current medication treatments for schizophrenia
  • Review and assess the history of integrative or “orthomolecular” mental health care
  • Identify and assess the potential of integrative schizophrenia treatments, including pregnenolone, omega-3 fatty acids, niacin, vitamin C, vitamin D, vitamin B6, zinc, folate, vitamin B12, minocycline, cannabidiol, N-acetylcysteine, glycine, taurine and L-theanine
  • Elucidate the relationship between inflammation, causes of inflammation and schizophrenia, including infections, celiac disease, diet and gut flora disturbances

In order to receive AMA PRA Category 1 credit™, participants must do the following:

  • Read the learning objectives and faculty disclosures
  • Participate in the activity, review course content and learning strategies, resources and support materials provided
  • Complete the post-test and activity evaluation
  • Achieve a score of 80% or higher on the post-test

James Greenblatt, MD
Chief Medical Officer and Vice President of Medical Services
Walden Behavioral Care, Waltham, Massachusetts
Assistant Clinical Professor of Psychiatry
Tufts University School of Medicine
Boston, Massachusetts

MedicusCME requires instructors, planners, managers, and others in control of educational content to disclose all their financial relationships with ineligible companies over the previous 24 months. All identified financial relationships are thoroughly vetted and mitigated according to MedicusCME policy.

The faculty reported the following relevant financial relationships with Accreditation Council for Continuing Medical Education (ACCME)-defined ineligible entities related to the educational content of this CE activity.

James Greenblatt, MD has disclosed a financial relationship with Pure Encapsulations and Jaymac Pharmaceuticals for his role as consultant.

All other planners and faculty, including MedicusCME planners and managers, have no relevant financial relationships with ineligible companies to disclose. Any relevant financial relationships listed for planners or content contributors have been mitigated according to MedicusCME policies.

This activity is not supported by funds from an ACCME-defined ineligible company.

In accordance with the Health Insurance Portability and Accountability Act (HIPAA), this educational activity, especially when utilizing patient cases for learning demonstration, will not include individually identifiable health information.

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration (FDA). The planners of this activity do not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Other Educational Tools You May Like

Light on Schizophrenia: Revealing Causes and Solutions from an Orthomolecular Perspective

This book lays out the causes and contributors to schizophrenia from an orthomolecular perspective, along with solutions to address nutrient deficiencies, nutrient dependencies, and environmental toxins such as heavy metals. This book contains expertise from Dr. Hoffer’s 57 years of experience and success in treating schizophrenia, along with valuable new contributions from James Greenblatt, MD.

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